Psychosomatic Medicine and General Practice 2018-04-03T15:56:57+00:00 Olena Khaustova (Олена Олександрівна Хаустова) Open Journal Systems Psychosomatic Medicine and General Practice (PMGP) is electronic open-access medical journal. It covers such medical disciplines as psychosomatics, psychiatry, medical psychology, psychotherapy, neurology, therapy and general practice The effect of selective serotonin reuptake inhibitors on the hemostasis system in patients with craniocerebral trauma 2018-04-03T15:56:57+00:00 Volodymyr Bedlinskyi <p><strong>Background.</strong> Due to the increased prevalence of depressive disorders, the demand for antidepressants also increases. One of the most popular pharmacological groups is selective serotonin reuptake inhibitors. Although, their admission not always can be safe in some categories of patients, among formers can be patients with head injuries.</p> <p><strong>Aim.</strong> Main mechanisms of SSRI negative influence on hemostatic system analysis in patients with depression and TBI. Finding ways to solve this problem.</p> <p><strong>Methods.</strong> The bibliographic databases such as Pubmed, Web of Science and Google Scholar for keywords: organic depression, disorder, depression, SSRI, TBI, hemostasis changes were analyzed.</p> <p><strong>Results.</strong> The general information about serotonin, its role in neurotransmission and the influence on the hemostatic system were studied. There’re shown the main mechanisms of SSRI influence on intra-thrombocytes serotonin. The main risk factors for SSRI admission in patients with depression with TBI were studied. We also have studied the SSRI admission in these painful patients. Some ways of solving the problem of treatment of patients with depression on the background of TBI are proposed.</p> 2018-03-30T23:47:21+00:00 ##submission.copyrightStatement## Transformation of personality features and coping strategies depending on the duration of recurrent depressive disorder 2018-04-03T15:56:57+00:00 Galyna Kalenska Nataliya Maruta Viktoriya Fedchenko Tamara Panko <p><strong>Background.</strong> The high prevalence of recurrent depressive disorders and the severity of the medical and social consequences of the depression in the form of chronization, relapse, resistance, disorders of social functioning, quality of life and suicidal behavior place the problem in the rank of the most urgent, requiring study in terms of early diagnosis and assessment of the condition, depending on the duration of the disease.</p> <p><strong>Methods.</strong> An integrated approach was used including clinical-psychopathological, psychodiagnostic and statistical methods. 40 patients with recurrent depressive disorders were examined, 35 people without mental disorders were included in the comparison group.</p> <p><strong>Results.</strong> The structure of clinical-psychopathological manifestations of the depressive spectrum in patients with the recurrent depressive disorder was characterized by the presence of affective, motivational-will, cognitive, psychomotor and somatic disorders. Among the personality features, patients differed in a more actualization of the non-adaptive copy-strategy and low self-actualization.</p> <p><strong>Conclusion.</strong> Data which we received should be considered when conducting diagnostic and psychotherapeutic interventions for patients with the recurrent depressive disorder.</p> 2018-03-14T18:16:57+00:00 ##submission.copyrightStatement## Acetaminophen (paracetamol) reduces sex hormones level 2018-02-21T14:50:01+00:00 Vitaliy Bezsheiko <p>Medication was not as safe as previously thought.</p> 2018-02-21T14:50:00+00:00 ##submission.copyrightStatement## Criteria for limited sanity in persons who have committed criminal sexual offenses 2018-04-03T15:56:57+00:00 Elena Kozerackaya <p>The results of scientific research conducted within the framework of the doctoral thesis "Forensic psychiatric evaluation of persons who have committed sexual criminal offences." For the purpose of the study, the author analyzed 279 cases of forensic psychiatric examinations of persons who committed the sexual offence and were at the forensic psychiatric examination in Kiev Center for Forensic Psychiatric Examination during 2001-2015 (15 years). To determine the relationship between the degree of opportunities to realize their actions/manage them and expert's conclusion, from the group of compos mentis was derived a group of partially compos mentis patients; it was formed artificially, based on the national concept of "limited sanity". As a result, we have identified socio-demographical and clinical criteria for "limited compos mentis" in forensic psychiatric examinations of persons who have committed sexual offences.</p> 2018-02-20T12:10:12+00:00 ##submission.copyrightStatement## The effectiveness of selank in the treatment of adjustment disorder 2018-04-03T15:56:57+00:00 Georgiy Verbenko Viktoriya Verbenko <p><strong>Background.</strong> Adjustment disorder (AD) is one of the most common mental disorders. Considering the social and economic situation in Ukraine at present, in almost 50% of the population, there are non-psychotic mental health disorders, and this number tends to increase. Individual risk factors that are particularly important for the AD development include the experience of a significant stress in childhood, problems with mental health in the past, difficult life circumstances, etc. At the same time, pathogenetically approaches to AD therapy are not fully understood. Pathogenetically oriented therapy of AD should be based on neurotransmitter causes and systemic therapeutic approach. The neurometabolic, anxiolytic, and psycho-stimulating action of the regulatory peptide allows it to be used in the therapy of psychogenic adaptation disorders.</p> <p><strong>Methods.&nbsp;</strong>Clinical manifestations of the AD were studied in different age groups - 21-34 years (n=153), 35-50 years (n=257), 51-65 years (n=167) using the Patient Health Questionnaire (PHQ) and Questionnaire of Stress Resistance (QSR). For the study on the effectiveness of the selank (a synthetic analogue of the immunomodulatory peptide tuftsin) were included 30 patients with the AD. Main (experimental group) received selank for two weeks; the control group didn’t receive any treatment (wait list). Patients were monitored for additional two weeks after the treatment with an assessment at the end of follow-up.</p> <p><strong>Results.&nbsp;</strong>According to the study results, selank significantly reduced PHQ score in patients with AD compared to control group. PHQ scores in the selank group after 2 weeks of follow-up were significantly lower for somatic symptoms (mean score 1.2 vs. 3.6; p&lt;0.05), nutritional problems (0.1 vs. 3.4; p&lt;0.05), and alcohol misuses (0.3 vs. 1.5; p&lt;0.05).</p> <p><strong>Conclusions.</strong> The use of the synthetic analogue of the immunomodulatory peptide tuftsin has a therapeutic effect on the somatic and mental symptoms of the adjustment disorder.</p> 2018-02-08T14:06:35+00:00 ##submission.copyrightStatement##