Abstract

From 1973 to 2011 the total sperm icount n the ejaculate decreased by 59.3% and continues to decrease by 1.6% annually.

This article was exposed to the machine translation from Ukrainian

Fertility (or the ability to produce an offspring) depends on the number, motility and morphology of spermatozoids in semen. These parameters, in turn, are influenced by several factors, including genes, diet, somatic health, hormone levels, mental well-being, age, habits and so on.

According to WHO recommendations referent values for lower limits on normal fertility are 1 :

  • The total number of sperm - 38 million per ejaculate.

  • Concentration - 15 million per ml.

  • Sustainability - 58% of live sperm.

  • Morphologically normal forms - 4%.

  • General mobility - 40%.

Note that a man can be fertile / subfertile even when the above indicators are below normal, but the likelihood of this is much lower than in the general population. In other words, these values are not absolute for each man.

Sperm quality deterioration problem is well known from at least the early 90s, when a group of scientists from the University of Copenhagen published the results of a survey of men for over the past 50 years, in which was noted the decrease in the average sperm count from 113 million to 66 million and semen volume from 3.4 ml to 2.75 ml 1 . However, these data were subjected to criticism and were counted as controversial, though they were repeated in other studies.

To solve this disputation an international team of scientists from the US, Norway, Spain and Israel conducted systematic review and meta-analysis of all available today studies on this subject 2 . They have reviewed 2510 and selected 185 studies with best design for further analysis. Thus, covered 42,935 men and the period from 1973 to 2011.

The results of this analysis appeared stunning:

  • According to a simple linear regression (statistical model with one independent variable) each year, the concentration of sperm in semen decreased by 0.7 million units per year (95% confident interval -0.72 ... -0.69, p <0.001) or 0.75% and a total sperm count - by 28.5%. The total number of spermatozoids in semen decreased by 2.23 million units per year.

  • According to the adjusted meta-regression model sperm concentration among the general population of "Western Men" decreased by 1.38 million units per mL per year (-2.02 ... -0.74, p <0.001), but among fertile - by 0.68 million units per mL per year ( -1.31 ... -0.05, p = 0.033). The total number of sperm in the ejaculate decreased from 337.5 million in 1973 to 137.5 million in 2011 or by 59.3% (1.6% / year). This trend continues today.

According to the researchers, these data can be extrapolated only on North America, Europe and Australia, as studies conducted in these regions showed a significant decrease in the number and concentration of sperm in semen. In South America, Asia and Africa such changes were not observed, which could be due to a real absence of this phenomenon or the lack of statistical power of studies that were conducted there.

Researchers noted that the decrease in sperm quality indicates not only problems with the reproductive function. It is also a measure of overall male health. Earlier was showed correlation between this indicator and the overall male mortality and morbidity. These results indicate the need for immediate searching the solution for this problem.

  1. World Health Organization reference values for human semen characteristics Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, Haugen TB, Kruger T, Wang C, Mbizvo MT, Vogelsong KM. Human Reproduction Update.2010;16(3):231-245. CrossRef PubMed Publisher Full Text
  2. Evidence for decreasing quality of semen during past 50 years Carlsen E, Giwercman A, von Eckardstein S, Keiding N, Skakkebaek NE. BMJ.1992;305(6854):609-613. PubMed Publisher Full Text
  3. Temporal trends in sperm count: a systematic review and meta-regression analysis Levine H, Jorgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Mindlis I, Pinotti R, Swan SH. Human Reproduction Update.2017. CrossRef Publisher Full Text